CONTRAVERSIES IN VACCINATION
Copyright 2004-2006
ERIC N. RYDLAND, M.D.
Children’s Holistic Health Centers
13205 S.W. 137 Ave
Suite 211, Miami, FL. DrRydland@kidswellness.comwww.kidswellness.com
WHAT ARE VACCINES?
Purified preparations obtained from viruses or bacteria grown in laboratories
Modified to prevent the disease
Dead or live organisms
Usually injected, rarely oral or nasal
WHY ARE THEY GIVEN?
Diseases exist and are potentially serious
Public vs. individual rights (to protect the public from epidemics)
Concept of herd immunity (prevent epidemics if enough vaccinated)
Protect the individual
THE DECISION
What are the risks of the disease?
How likely is my child to get the disease: general health (i.e. constitution), risk factors, etc.
What are the risks, efficacy of the vaccine?
When, what vaccines, how to give
Legal considerations
VACCINE "PREVENTABLE" ILLNESSES
Diphtheria
Tetanus
Pertussis (whooping cough)
Polio
Hemophilus Influenza type B
Hepatitis A and B
Pneumococcus (Prevnar or PCV 7)
VACCINE "PREVENTABLE" ILLNESSES
Measles (L) [L=live virus vaccine]
Mumps (L)
Rubella (German Measles) (L)
Varicella (Chicken Pox) (L)
Influenza (L)
Rabies
Meningococcus
VACCINE "PREVENTABLE" ILLNESSES 3
Typhoid
Smallpox
Anthrax
Tuberculosis (BCG)
Others for special circumstances, e.g. yellow fever, Japanese encephalitis, Lyme, etc.
Others in development (rotavirus, HPV)
DIPHTHERIA
Now a rare disease, <10/yr. In U.S.
Corynebacterium diphtheriae bacteria
80% of cases <15 yr. Old
Mostly in poor and crowded conditions
Respiratory spread
1-6 day incubation period
DIPHTHERIA
Toxin produces tissue necrosis in nose, lungs, trachea, throat membranes
Toxin in bloodstream: may affect heart, nerves and kidneys
Treatment (conventional): antitoxin, antibiotics, bed rest, fluids, tracheotomy (rare)
Mortality 10%
TETANUS
Rare disease, <50/yr
Clostridium tetani bacteria (toxin)
Bacteria found in soil, house dust, fresh and salt water, animal feces
Most common age 1-5 yr old, neonatal tetanus still occurs in areas
Colonization at umbilicus, traumatic injury
TETANUS
Incubation usually 3-14 days
Toxin inhibits nerves that relax muscles, may move along the nerves
Generalized disease most common, also local and cephalic (brain)
Seizures, muscle spasm may cause lack of oxygen to tissues
TETANUS
Treatment: antibiotics, muscle relaxants, neuromuscular blocking agents, supportive care in hospital
Mortality of 30-65%, highest rates in younger and older
PERTUSSSIS
Still a common illness, 1000-8000/yr. in U.S.
Bordatella pertussis bacteria
97-100% contagious, affects all ages
Respiratory spread
Respiratory tissues swollen, thick mucous, obstruction of airways
Liver and brain may be affected
PERTUSSSIS
Incubation period 6-20 days
Begins with cold-like symptoms 1-2 wk.
Severe symptom period follows, 2-4+ wk.
1-2 wk. of gradual recovery
Treatment: antibiotics, steroids, fluids, supportive
Less than 1% mortality, higher in young
POLIO
Becoming increasingly rare
Only cause in U.S. since 1979 is live vaccine
Live vaccine last sold (U.S.) 1/2000
Caused by Poliovirus
Fecal-oral spread (items contaminated by virus in feces)
Incubation 3-7 days
POLIO
Most cases have minor or no symptoms
Intestinal, respiratory and muscle symptoms
Treatment mostly supportive
Mortality unknown, was 5-7 % prevaccine
Unexpected improvement may occur
HEMOPHILUS INFLUENZA B
Almost exclusively in children <7 yr.
Bacterial illness
Rate has declined since vaccine
Was major cause of meningitis 1 mo.-3 yr., other infections incl. epiglottitis
peak in 6-9 mo. 80% <18 mo.
HEMOPHILUS INFLUENZA B
More common in day care
Respiratory spread
Meningitis mortality 2-18%, permanent nerve damage 20%, additional 5-10% hearing deficits
Treatment: antibiotics, steroids, fluids
HEPATITIS A
Common virus
Mostly in epidemics or "endemic" (usually "developing") countries
Affects the liver
May easily spread in day care-hygiene
Highly contagious, fecal-oral spread
Incubation period 4-6 wk.
HEPATITIS A
Doesn’t affect baby of infected mother
Treatment supportive, fluids
Illness may last for months, usually complete recovery
Rarely a serious illness
Vaccine recently recommended 1-23 months old
HEPATITIS B
Uncommon in young children
Risk factors sexual contact, birthing, shared needles, blood, institutional living, (possibly) breast milk
Viral infection
Exchange of blood and body fluids, detected in saliva
HEPATITIS B
Routine prenatal blood test
Incubation period 2-5 mo.
May cause progressive liver failure
Associated with an increase of liver cancer
PNEUMOCOCCUS
(PCV 7)
Affects all ages
Bacterial infection
More than 80 strains of this bacterium
Seven most common strains of childhood illness in the PCV 7
Meningitis in children 6 mo.-4 yr.
Also other infections, e.g. pneumonia, ear infections, etc.
PNEUMOCOCCUS
(PCV 7)
More serious in sickle cell, asplenia, immunodeficient, nephrosis
Frequently follows upper resp. infection (cold)
Treatment, antibiotics, steroids, fluids, supportive
5-10% mortality, increased risk of neurological events
MEASLES
Rare disease now
Viral infection, respiratory spread
Occurs in epidemics about every 2-4 yr.
Highly contagious, >90% if susceptible
Incubation period 10-12 days
Contagious for up to 3 days before illness
MEASLES
Have occurred in highly vaccinated populations, especially adults
Treatment supportive
Complications of encephalitis and subacute sclerosing panencephalitis potentially cause permanent nerve damage
Rarely fatal, 68 deaths-last epidemic of ~38,000 cases in U.S.
MUMPS
Viral illness spread through direct, respiratory, fomites (saliva)
Incubation period 14-24 days
30-40% subclinical
Usually mild except perinatal (near birth)
Affects salivary glands, pancreas, brain, testes, ovaries
MUMPS
Meningoencephalitis 2.5/1,000, leading to death in 2% of those affected
Orchitis in 14-35%, impairment in fertility 13% male, not in female
Deafness in 1/15,000
Treatment is supportive
RUBELLA
Usually mild self-limited illness
Hazard is to fetus only, except in very rare cases
Viral illness, respiratory or transplacental spread
Highly contagious, up to 100%
Epidemics every 6-9 years
RUBELLA
Incubation period 14-21 days
Risk of congenital defects prenatally: ~100% 1st mo., 40% 2nd mo., 10% 3rd mo., 4% thereafter—neurologic, hearing, immune, rashes, diabetes, (rarely) death
Childhood complications rare, include arthritis, neuritis, no specific treatment
VARICELLA
(chicken pox)
Very common illness prior to vaccine
Since vaccine ~1996 declining frequency
Rarely serious in children after neonatal period (perinatal varicella 20% mortality)
Becomes more serious in teens, adults
Incubation period 11-21 days
Subclinical (not diagnosable) in ~15%
VARICELLA
Viral illness; direct contact or droplet spread; highly contagious
Complications mostly skin infections, rarely hemorrhage, Reyes, congenital malformations (rare), pneumonia (mostly adult), encephalitis and other neurologic (rare); immunosuppressed more susceptible to complications
NO ASPIRIN in children with varicella (may cause Reyes Syndrome)
INFLUENZA
Viral infection, attack rates up to 50%; respiratory spread
Newest recommended vaccine
Epidemics occur every 2-3 years (minor), 4-7 years (major), due to changes in virus
Incubation period 2-3 days
INFLUENZA
Vaccine previously only for children with severe lung, heart or immune disease
Most common complications of disease are bacterial infections: respiratory, ear, also heart and Reyes syndrome (NO aspirin)
INFLUENZA
Prognosis generally good except for high risk children, (possibly) healthy infants and toddlers
My natural recommendations are listed at www.kidswellness.com
REQUIRED VACCINES
(most states)
OPTIONAL VACCINES
VACCINE ABREVIATIONS
DTaP: diphtheria, tetanus and pertussis
HIB: hemophilus influenza type B
HBV: hepatitis B
PCV 7: pneumoccus
MMR: measles, mumps, rubella
VZV: varicella (chicken pox)
HAV: hepatitis A
FLU: influenza
VACCINE THEORY
Prevent serious illness in recipient
Possibly prevent illness in unvaccinated
Several small doses cause immune response
Conventional medicine touts success
Alternative practitioners-success from other factors
Who is right?
VACCINE COMPONENTS
Live vs. "attenuated", dead organism
Culture media (e.g. beef heart, monkey kidney, eggs, aborted fetal lines [Varicella, Rubella], etc.) the organism grown in
Thimerosal (mercury-in some dead vaccines)
Aluminum (0.11-0.625 mg./dose [dead])
Formaldehyde [dead]
"Piggyback" or contaminant viruses [live]
VACCINE COMPONENTS
Multiple antigens/proteins
Buffers
Polysorbate 80
Gelatin
Glycine
Lysine
Sucrose
VACCINE COMPONENTS
Polyethylene glycol
Ether
Antibiotics
Yeast
Soy
Dextrose
Detergents
VACCINE COMPONENTS
2-phenoxyethanol (preservative)
Sodium, potassium chloride
Sorbitol
MSG
Others, incl. preservatives, buffers, etc.
VACCINE REACTIONS
Most immediate (first 2-3 days) vaccine reactions are mild
Severe reactions can and do occur to each vaccine
Vaccines thought (by "alternative/integrative") to shift immune system toward autoimmunity (immune system attacking normal body tissues)
Long-term, slowly progressive and permanent reactions unknown
Some are vehemently debated
REACTIONS-DTaP
Frequency ~25%, most minor, include:
Local reactions (e.g. swelling, redness, pain), sterile abcess, nodule, headache, fever, chills, weakness, fatigue, cellulitis, dizziness, drowsiness, irritability, aches and pains, flushing, tachycardia, fainting, nausea, vomiting, diarrhea, swollen glands, phlebitis, muscle and joint pains, itching, hives, sweating, EEG changes, myelitis,
REACTIONS-DTaP 2
Reactions, continued:
fever, decreased appetite, myelopathy, "acute midbrain syndrome", paralysis of other motor and sensory nerves, persistent crying or fretfulness, cochlear (balance system) lesions, convulsions, encephalopathy, Guillian-Barre
ì syndrome (GBS), neuropathies, erythema multiforme, anaphylaxis, shock, death (+14/29,000)
REACTIONS-HIB
Approx 20%, listed ones include
Sleepiness, persistent crying, irritability, local reactions, vomiting and diarrhea, appetite loss, rash, fever, unusual crying, drowsiness
REACTIONS-HIB
Reported "possible" side effects include:
Hives
Erythema multiforme
Convulsions
Guillian-Barre
ì syndrome
Renal (kidney) failure
REACTIONS-HBV
Overall over 30-40% reactions include:
Local reactions, fever, irritability, dizziness, somnolence (excessive sleep), headache, itching, bruising, sweating, cold-flu symptoms, weakness, flushing, nausea, decreased appetite, vomiting, diarrhea, constipation, hypotension (low blood pressure), swollen lymph glands, sore/stiff muscles/joints, hives, arthritis, asthma, tachycardia, rash
REACTIONS-HBV
Reactions, continued:
anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, conjunctivitis, ear infections, GBS, MS (Multiple Sclerosis-?), seizures, diabetes (?), eczema, hair loss, tinnitus (ringing in the ears), migraine, motor and sensory nerve disorders, Bell’s palsy, SIDS, autism (?)
REACTIONS-POLIO
40+% fever, irritability, tiredness, also anorexia, vomiting, local reactions, fever, fussiness, sleepiness, crying, GBS, death (uncertain)
REACTIONS-MMR
Overall approximate frequency 30-40%
Fever, skin rash, cold symptoms, headache, dizziness, irritability, nausea, vomiting, diarrhea, bruising, low platelets, high white blood cells, swollen lymph glands, fainting, vasculitis, anaphylaxis, bronchial spasm, encephalitis, encephalopathy, SSPE ("subacute sclerosing panencephalitis"), GBS, convulsions, ataxia, eye nerve palsies, pneumonia, deafness
REACTIONS-MMR
Reactions, continued:
Stevens-Johnson syndrome, hives, local reactions, arthritis, ear infections, sore throat, cold symptoms, ear infections, fainting, conjunctivitis, atypical measles, arthritis, various eye conditions (papillitis, optic neuritis, retrobulbar neuritis)
REACTIONS-MMR
Reactions, continued:
Neurologic conditions (polyneuritis, polyneuropathy, paresthesia), autism (debated, probable), death (possible)
REACTIONS-VARIVAX
30-40% (up to 42 days after the vaccine), including fever, local reactions, rash, cold symptoms, cough, irritability/nervousness, fatigue, disturbed sleep, diarrhea, anorexia, vomiting, ear infection, diaper rash/contact rash, headache, malaise, abdominal pain, nausea, eye complaints, chills, swollen lymph glands, myalgia, allergic reactions (incl. rash, hives), stiff neck, arthralgia, febrile seizures,
REACTIONS-VARIVAX
canker sores, encephalitis, anaphylaxis, low platelets, non-febrile seizures, GBS, transverse myelitis, Bell’s palsy, ataxia, sore throat, Stevens-Johnson syndrome, erythema multiforme, Henoch-Schoenlein purpura, impetigo, cellulitis, herpes zoster
REACTIONS-PCV 7
50+%, including fever, irritability, local reactions, drowsiness, restless sleep, anorexia, vomiting, diarrhea, rash, hives, allergic reactions, shortness of breath, bronchospasm, shock, erythema multiforme
REACTIONS-HEP A
20+%, including local reactions, fever, abdominal pain, sore throat, headache, vomiting, diarrhea, cold symptoms, cough, fatigue, myalgia, back pain, nausea, "menstruation disorder", asthma, wheezing, swelling, rash, generalized erythema (redness of skin), hives, eye irritation/itching, dermatitis
REACTIONS-INFLUENZA
Reaction frequency 10-64%, include:
Local reactions, fever, malaise, myalgia, headache, itching, dizziness, nausea, vomiting, diarrhea, arthralgias, myalgia, swollen lymph glands
REACTIONS-INFLUENZA
Rare complications:
Hives, asthma, anaphylaxis, Guillian-Barre
ì syndrome (1/50,00-100,000 doses), encephalopathy, optic nerve disorders, facial paralysis, brachial nerve disorders, vasculitis, labyrinthitis, encephalitis, meningitis
POSSIBLE OTHER VACCINE REACTIONS (controversial)
Immune depression
Autoimmune reactions (MS, diabetes, lupus, CFIDS)
Other viral infections
Reactions to foreign tissue
Others, presently unknown
RYDLAND FIVE FINGER RULES FOR VACCINES
BEFORE GIVING VACCINES:
SHOULD BE HEALTHY
ONE VACCINE AT A TIME
PREPARE IN ADVANCE
ONLY MOST IMPORTANT
LEGAL CONSIDERATIONS
BE HEALTHY
Never, never, never
give any vaccine when a child has any acute illness or infection
If necessary wait until most of the symptoms are gone, otherwise when completely well for several days
Remember that vaccines require the immune system to act—immune stress